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It can take 6-8 weeks to titrate to the typical ceiling dose of 200-300 mg day, because tolerance to the side effects of topamax builds slowly.
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Research has also linked the use of the drug during pregnancy to a risk of topamax birth defects, such as cleft lips, cleft palates, genital defects and other birth malformations.
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topamax topiramate is not recommended for treatment or prevention of migraine in children due to insufficient data on safety and efficacy.