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One clinical study of several hundred people with major depression indicated that paxil was associated with significant weight increase, prozac with a modest, not-significant weight loss, and zoloft with a minor and not significant weight gain.

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Voluntary reports of adverse events in patients taking paxil that have been received since market introduction and not listed above that may have no causal relationship with the drug include acute pancreatitis, elevated liver function tests the most severe cases were deaths due to liver necrosis, and grossly elevated transaminases associated with severe liver dysfunction , guillain barr syndrome, stevens-johnson syndrome, toxic epidermal necrolysis, priapism, syndrome of inappropriate adh secretion, symptoms suggestive of prolactinemia and galactorrhea; extrapyramidal symptoms which have included akathisia, bradykinesia, cogwheel rigidity, dystonia, hypertonia, oculogyric crisis which has been associated with concomitant use of pimozide; tremor and trismus; status epilepticus, acute renal failure, pulmonary hypertension, allergic alveolitis, anaphylaxis, eclampsia, laryngismus, optic neuritis, porphyria, restless legs syndrome rls , ventricular fibrillation, ventricular tachycardia including torsade de pointes , thrombocytopenia, hemolytic anemia, events related to impaired hematopoiesis including aplastic anemia, pancytopenia, bone marrow aplasia, and agranulocytosis , vasculitic syndromes such as henoch-sch nlein purpura , and premature births in pregnant women.

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paxil should not be taken with the following medications .

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